I am very confident in saying that MK-677 is without a doubt the best legal HGH alternative available on the planet right now.
What Exactly Is MK-677 (Ibutamoren)?
MK-677 is a GH secretagogue taken orally (no injections needed). A GH secretagogue is simply a substance that signals the pituitary gland in your body to secrete more growth hormone.
Much like SARMs, it is non-steroidal, but contrary to popular belief, MK-677 is NOT a SARM in any capacity, despite commonly getting thrown into that category.
MK-677 will not negatively affect your testosterone levels in any capacity at all, so there is literally NO chance of any hormonal suppression. Consequently, you don’t need to take an aromatase inhibitor or complete a PCT phase after taking MK-677.
Right when this compound seems too good to be true, it gets even better. After orally taking a dose of MK-677, the compound will vastly increase the release of Growth Hormone (GH) and Insulin-Life Growth Factor 1 (IGF-1) for the next 24 hours via strong GH pulsations exerted in the pituitary gland.
These strong GH pulses MK-677 causes your body to create are much like the growth hormone releasing peptides that you may be more familiar with like GHRP-6, GHRP-2, Ipamorelin and Hexarelin.
The amazing thing, MK-677 causes over a dozen of these extremely strong GH pulsations over the next 24 hours from a single dose, and they don’t need injections at all like ALL other growth hormone releasing peptides require.
Clinical trials are currently being extensively studied to assess how well MK-677 can address growth hormone deficiencies, muscle wasting diseases, Osteoporosis and a myriad of other related conditions. To say the least, MK-677 has proven to be exceptional in ALL of these studies. It actually caused overall increases in bone mineral density in humans and drastically increased lean muscle mass.
Promising new agents in osteoporosis
MK-677 also greatly improves your ability to burn fat, thus making it a very viable option for the treatment of obesity in the future.
There are clinical studies exceeding 2 years of constant use of MK-677 on the subjects involved, and all of them had no notable negative side effects, and it has proven to be a very safe compound for long-term use.
Methods for treating sarcopenia with a growth hormone secretagogue. or increasing muscle mass to treat sarcopenia
Just Some Of MK-677’s Incredible Attributes:
- MK-677 doesn’t require any injections as it has a high level of oral bioavailability
- Only one dose is needed per day to reap ALL the benefits MK-677 has to offer while synthetic HGH injections and GH peptide injections need to be pinned SEVERAL times per day which can be a nuisance, not to mention extremely inconvenient if you are traveling (good luck storing your HGH and peptides in a fridge and getting all your injections in each day while traveling).
- MK-677 causes 12 very strong GH pulsations from your pituitary gland after ingestion (you would need to inject GHRP-6 12+ times per day to achieve this same benefit from peptides)
- It is stored at room temperature making it convenient for travel (HGH and GH peptides NEED to be stored in a fridge like I mentioned previously)
- IGF-1 levels continue to increase with each consecutive day of use to extremely high levels (each consecutive dose continuously increases how much muscle your body is capable of packing on)
- Body fat melts off so much easier
- Weight gain is rapid and very noticeable (in a good way). It isn’t uncommon for someone to gain up to 10 pounds within their first week of using MK-677
- Sleep quality is deeper and DRAMATICALLY improved from the increased GH output
- Endurance is greatly enhanced
- Improvement of your complexion
- Dramatic increases in nitrogen retention result in crazy muscular fullness
- Big increases of strength
- Immune system operates at a heightened level
After MK-677 Is Taken What Can You Expect?
After ingestion, MK-677 signals the pituitary gland to secrete more growth hormone.
MK-677 will then stimulate your pituitary gland to release over a dozen very strong GH pulses over the next 24 hours after ingestion.
These intense GH pulses are what is responsible for the very potent effect the MK-677 will have on your physique in such a short period of time, as well as for how it will drive your IGF-1 levels continuously up so dramatically over the span of its use.
Growth hormone is made in the anterior pituitary gland, is released into the blood stream, and then stimulates the liver to produce IGF-1
These Growth hormone pulses are very strong, and you can even increase the intensity of each by inhibiting Somatostatin receptor signalling.
How Higher GH Levels and IGF-1 Levels Can Help You And Why You Should Care
There are several positive benefits that you will get from elevated levels of GH and IGF-1 in your body. These benefits even include anti-aging properties, thus why HGH is commonly referred to as the real “fountain of youth.”
HGH promotes and increases the synthesis of new protein tissues, allowing new muscle to be built, it metabolizes fat incredibly well, improves complexion, has dramatic anti-aging properties, increases hair growth (where you want it), it improves sleeping patterns (making for fewer unintended awakenings and better REM-stage sleep), it produces more energy, it may improve sexual performance, it increases bone density which prevents injury and helps promote healing and it improves the quality and duration of heart and kidneys.
IGF-1 supports cellular division, making it the only hormone that can actually create brand new muscle cells via muscular cell division.
It also repairs nerve damage, lowers body fat levels, and also exhibits anti-aging properties by tightening up loose skin, healing old injuries, as well as healing bones, tendons and ligaments.
The cellular division aspect of IGF-1 is what makes it so attractive to bodybuilders and athletes, because when you hear of “genetic potential” it refers to how much hypertrophy you can cause in your current muscle cells.
You can only max these out so much, even with the addition of anabolic steroids or insulin.
After you have done this, literally the only thing that will let you break through that plateau is HGH and IGF-1, as (in layman’s terms) you will be able to create new muscle cells, and then you have those new cells that you can cause hypertrophy in and max out.
As a result, you have a seemingly unlimited amount of muscle growth potential the higher you drive your IGF-1 levels up.
MK-677 will give you ALL the benefits mentioned above that HGH and IGF-1 provide. Not to mention that MK-677 WILL NOT cause your natural GH production to diminish or shut down.
I like to refer to MK-677 as “the poor man’s GH” because it literally does exactly what high quality HGH does, but for a tiny faction of the price of GH!
Many individuals consider GH superior to steroids because it is not androgenic, causes no aromatization, and shows few side effects. MK-677 is arguably the strongest natural research product with the least side effects available on this planet at the moment.
MK-677 Has Proven Amazingly Effective In Clinical Studies
There are several readily available studies demonstrating how effective MK-677 is. For your reference, here are just a few of them:
In a study assessing its’ effects on muscular catabolism, a once daily oral dose of 25 mg was given to healthy young men subjected to short-term diet-induced nitrogen wasting:
Results: “After only 7 days of this dose, each and every subject showed sustained increases in serum concentration of IGF-1 and Growth Hormone levels. Also, the diet induced nitrogen wasting was totally reversed. MK-677 literally completely stopped potential muscle wasting within 7 short days.”
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.
Results: “Once daily treatment of older people with oral MK-677 for up to 4 weeks enhanced pulsatile GH release, significantly increased serum GH and IGF-I concentrations, and, at a dose of 25 mg/day, restored serum IGF-I concentrations to those of young adults.”
Repeat administration of the GH secretagogue MK-677 increases and maintains elevated IGF-I levels in beagles:
Results: “We have reported that MK-677 is a novel, orally active GH secretagogue that stimulates an immediate and long-lasting increase in serum GH levels in dogs. Significant elevations in IGF-I levels were associated with the increased GH secretion. Individual beagle GH profiles indicated that the increased GH concentration was associated with an amplified GH pulsatile profile. Serum IGF-I levels were significantly increased over control levels at all dosage levels by 480 min on the first day of MK-677 administration. With repeated administration, IGF-I levels were increased up to 126%. In summary, chronic oral administration of MK-677 was associated with significant increases in GH and IGF-I levels that were maintained for the duration of the treatment.”
Anti-Aging – Ghrelin-mimetic 2 year clinical study – Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults A Randomized Trial
Results: “The ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated.”
I have several friends and acquaintances who ALL have nothing but good things to say about this compound as well. These logs are anecdotal, but have experiences that are more than insightful and helpful for determining what MK-677 is capable of.
I find anecdotal logs from fellow bodybuilders and serious athletes substantially more revealing of the information I’m looking for than clinical studies anyways. I’ll start with my personal experience with MK-677.
A customer that has used MK-677 a few times over the past couple years now.
Each time the results have been nothing short of dramatic, and this is even WHILE ON moderate doses of anabolic steroids.
The fact that he notice a big difference in his physique and strength from this stuff while on heavy duty anabolics is nothing short of incredible.
He used a dose of 25 mg per day (recommended dose) and within 2 days his muscles would get very, very full and pumped.
My weight would shoot up incredibly fast as well.
Within a week I would be up 10 pounds, and already see a huge difference not only in my physique, but my strength levels at the gym.
Whenever I start MK-677, I notice a dramatic difference literally within the first few days.
If I had to compare it to something I would compare the results to that of a low dose of Dianabol with 6-8 iu’s of high quality generic HGH.
The joint lubrication is excellent too from the drastic increase in muscular fullness brought on by MK-677, it definitely allows you to use heavier weights without as much of a risk of injury.
Other Anecdotal Cases:
I have lost count of how much positive feedback and how many rave reviews I’ve heard from my friends, other bodybuilders, athletes, and just average joe gym goers about MK-677.
The most common characteristic between each review each individual had was their direct comparison they said MK-677 was to HGH.
Time and time again I heard back how potent this stuff is, and how its “the same as taking high quality HGH!”.
Their reviews continued raving about how there is no refrigeration necessary, it’s legal, doesn’t need to be injected, but it provides all the same benefits of synthetic HGH for a WAY cheaper price.
Many of those same reviews came from guys who soon after completely stopped buying HGH and simply use MK-677 now because it is THAT GOOD.
Better sleep, skin quality improvements, tingly/numb fingers from the heavy GH pulses, extremely muscular fullness, ravenous appetite, improved fat loss, and huge increases of strength in the gym were all common results found among the cycle reviews I have heard over the past few years.
Comparisons are constantly made between MK-677 and how many iu’s of HGH its results can equate to.
The consensus among users is that MK-677 at a dose of 25mg per day provides the same results you could expect from 6-8 iu’s of high quality synthetic HGH.
This is incredible because that dose of real HGH would easily cost upwards of $1500-2000 per month.
How to Dose MK-677/Cycle Duration
GH levels will increase dependently upon your chosen dose you conduct your research with. Studies had were shown to increase dose dependently, at doses starting at 5 mg per day up to 100 mg per day in the more extreme clinical trials.
However, the most commonly utilized dose in several clinical studies, and is widely known as the “recommended dose” in anecdotal logs made by researchers is 25 mg per day as it provides the maximum benefit with the least side effects.
The half-life of MK-677 is 24 hours; so taking your daily dose all at once each day is fine. I do recommend having your dose pre-bed though, as the initial GH pulses after dosing can make some individuals feel tired (high quality GH will do this).
By having your dose pre-bed, you can offset the tired feeling as you will be going to bed anyways, and then by the time you have to go to work the next time you won’t be affected as much by the lethargy.
As far as cycle duration goes, that is ultimately up to you.
There is no shutdown of natural GH production with MK-677, nor is there a need for PCT, and there aren’t any long term side effects that have posed any reason for MK-677 to have a predetermined “safe” cycle length.
The clinical studies have exceeded years in study length without any issues or side effects, so in theory, you could run MK-677 for as long as you want without having to worry about desensitization of your pituitary gland or natural GH output.
You can literally run MK-677 for a year straight and be side effect free if you wanted to, with zero desensitization of the pituitary gland.
Although MK-677 can be used for long durations of time, I suggest for the cautious person to keep their cycle length around 12 weeks.
Although, you can run MK-677 into your PCT phase and onwards past your PCT and still reap the benefits of it. Many guys I know simply never come off and love it.
Some of the usual side effects that go with elevated GH levels such as numb hands, intense dreams, some lethargy, water retention, as well as increased appetite have been reported with the use of MK-677.
The water retention can indirectly cause an increase in blood pressure, which can be offset with increasing your water intake, cleaning up your diet, or taking mild diuretics if absolutely necessary (very rare).
MK-677 was found to be exceptionally safe and actually showed to reduce tumors in mice, which scientists believe was a result of the increased immune system response MK-677 can induce.
MK-677 Vs. Synthetic HGH Injections
The majority of competitive bodybuilders and physique athletes view growth hormone as a necessary stepping stone in their journey towards achieving physical perfection and maximizing their muscle growth and fat loss potential.
However, REAL HGH is simply unaffordable to most.
With a pharmacy-grade kit being upwards of $600-1000 in some instances, it can literally be equivalent to making a decent car payment each month to maintain your daily HGH dosing protocol.
Consequently, HGH is a drug that is essentially only available to those with a very high level of disposable income, not to mention those who are well connected in the bodybuilding world, as sourcing legitimate HGH is a difficult task in itself.
The black market for HGH is extremely unreliable, and as such, 90% of those who think they have tried “HGH” have actually probably just been injecting sugar water or GH peptides laced with anti-diuretics.
The cost of drugs in the world of bodybuilding easily crosses the threshold of insanity, and when adding a consistent HGH expense to your wallet comes into play, that is essentially where your line of sensible spending will go out the window if you want to run a dose high enough to notice even a mildly significant benefit from it.
However, now with MK-677 individuals can replicate the results they would get from a decent dose of HGH, without having to take out a second mortgage on their home!
I’ve personally seen IGF-1 levels in several different individuals’ blood work (the most accurate method of determining GH levels within the body) taking MK-677 reaching the equivalent of at least a 6-8 IU daily dose of growth hormone.
These results were achieved at a fraction of the cost of exogenous GH (literally 1/20th of the cost).
Of all the various GH elevating drugs at our disposal, MK-677 is easily pound for pound the best bang for your buck.
MK-677 Vs. Peptides
Obviously, for the needle averse, the fact that MK-677 has a high level of oral bioavailability and GH peptides don’t already is a huge benefit in favor of MK-677.
Also, you only need to take MK-677 once per day due to its 24-hour half-life.
Among the various other growth hormone releasing peptides, they all must be used 3-6 times per day in order to keep GH levels elevated for a decent period of time.
Although short duration GH peptides can be effective, even die-hard geared out of their mind bodybuilders would admit that pinning your abdominal fat with GH peptides every 3 hours, 6x per day, is a colossal pain in the ass.
Not to mention the fact that GH peptides need to be timed around your eating schedule so that you don’t have elevated blood glucose levels when you inject them, which would render them dramatically less effective.
You don’t need to worry about ANY of these things at all in any capacity when dosing MK-677.
Another benefit of MK-677 is that it doesn’t cause pituitary desensitization like other GHRP’s do.
Many GH peptides will cause desensitization within a short period of time.
To what degree will vary depending on which compound you are injecting, but some of them, such as Hexarelin, begin to cause desensitization by the 2nd dose, and within a couple weeks are extremely less potent than they were the first time you injected them into your body.
MK-677 exhibits no such downside and the research actually has proved that MK-677 can become more effective with long-term use. One clinical study measured an increase in IGF-1 levels by 60% at the 6 month point and 72.9% after 12 months of treatment.
Some GH peptides (GHRP-6 most notably) are notorious for stimulating your appetite.
After injection, ghrelin is released in your body, resulting in an extremely dramatic increase in your hunger.
MK-677 has the same effect in your body; however, the effect is much longer lasting with MK-677 as it releases GH in a pulsatile manner around the clock for 24 hours.
This proves to be a very beneficial attribute for those looking to gain muscle and pack on size as the appetite increase MK-677 provides is nothing short of substantial.
Ultimate Bulking Stacks and Cutting Stacks In Conjunction With MK-677
A sample cycle of a very productive bulk phase is outlined below:
Week 1-12: LGD-4033 10mg per day dosed once per day in the AM
Week 1-12: MK-677 25mg per day dosed once per day pre-bed
Week 1-12: 1 Pill ELIMINATE dosed three times per day
(Mini-PCT) Week 13-16: 5 Pills K1NGS BLOOD dosed twice per day
LGD-4033: Pound for pound the best SARM there is for overall mass gain. Use this alongside MK-677 in your off-season to gain anywhere between 10-15 pounds of LEAN MUSCLE.
A sample cycle of a very productive cutting phase is outlined below:
Week 1-12: Ostarine/MK-2866 25mg per day dosed once per day in the AM
Week 1-12: MK-677 25 mg per day dosed once per day pre-bed
Week 1-12: Cardarine/GW-501516 20mg per day dosed all at once 20 minutes pre-workout or before physical activity (if not doing physical activity that day have it in the AM)
Week 1-12: S4 50mg per day split into 2 doses per day…. 25mg in the AM and 25mg in the PM
Week 1-12: 1 Pill ELIMINATE dosed three times per day
(Mini-PCT) Week 13-16: 5 Pills K1NGS BLOOD dosed twice per day
Ostarine/MK-2866: Don’t get confused thinking that Ostarine and MK-677 are both SARMs that do the same thing.
If you read this article you will know that Ostarine works by exerting anabolic effects on skeletal muscle tissue like testosterone does, and MK-677 works by drastically increasing how much GH and IGF-1 your body produces.
These are two totally separate processes, and consequently, by stacking a potent SARM like Ostarine with a strong GH Secretagogue (MK-677), you can essentially replicate the results from a cycle stack of low dose Testosterone and moderate dose HGH without the unwanted side effects.
I recommend using the Ostarine product “OstaMuscle” alongside your MK-677 if you choose to stack the two.
Cardarine/GW-501516: Isn’t suppressive at all and provides HUGE endurance benefits as well as amazing fat loss properties
S4: The ultimate aesthetic SARM, it hardens and conditions the muscle, adds strength, increases lean muscle mass, and melts fat off you.