Ligandrol, also known as LGD-4033 is a popular testosterone boosting supplement that works as a selective androgen receptor modulator (SARM). Here’s everything you need to know about Ligandrol.
What is Ligandrol?
Ligandrol is a selective androgen receptor modulator (SARM) that is popular among bodybuilders and athletes for both bulking and cutting. At doses of 10mg per day, the supplement has been shown to lead to 5 to 10 pounds of lean mass gains every month.
In the bodybuilding and athletic worlds, Ligandrol is used as a side-effect free alternative to steroids.
Although Ligandrol can be used for both bulking and cutting, it appears to be more popular for bulking. There are stories of phenomenal weight gain progress while taking Ligandrol. As you’ll learn in the next section about quarterback Will Grier, sometimes these weight gains can be so significant that they arouse suspicion.
LGD-4033 is relatively strong compared to similar products. It has an anabolic/androgenic ratio of approximately 10:1. To put that ratio in perspective, testosterone’s ratio is 1:1. Some sources also claim that Ligandrol is 11 times stronger than its popular competitor, Ostarine.
Ligandrol LGD-4033 Background
Ligandrol (also known as LGD-4033, or LGD, or LGD4033) is touted by Bodybuilders as being a healthier replacement to the most powerful muscle building oral steroids Dianabol (Dbol or D-bol) and Anadrol (Drol).*
LGD-4033 binds to the androgen receptor of muscle and bone selectively, exhibiting similar effects as testosterone*, with only partial agonist activity on the prostate. It was developed as a way to treat diseases or conditions associated with muscle and bone deterioration. The advantage a SARM like LGD has over testosterone is the difference in activity it has on the body outside of muscle and bone.*
We are excited for more research to be done on LGD-4033 because this could be the future of hormone replacement therapy and the end of muscle wasting.* However, until it is prescribed by a doctor for personal use it is strictly prohibited for human consumption and it is for research purposes only.
We hope that someday steroids can be replaced with these SARMS and prescribed by Doctors giving all the benefits of Steroids with reduced or no side effects. Until prescribed by a doctor it cannot be ruled out that this compound will cause in humans death and serious bodily injury.
Anecdotal evidence shows that the human dosage may be around 10mg (5mg twice per day), although since LGD is in the class of drugs of SARMS and too powerful to sell as a supplement for human consumption, no recommended dosage has been approved. Once LGD passes all its FDA testing (approximately 10 years), a recommended dosage will be published and Doctors will be able to prescribe a dosage unique to the individual based on the guidelines.
Anecdotal evidence shows that human use of LGD-4033 will result in reduction of natural testosterone production. This is because the body thinks the compound is testosterone and therefore produces less. Therefore anyone who undergoes research with LGD should look into PCT Post Cycle Therapy to regenerate natural testosterone production and prevent a hormonal rebound of hormones such as estrogen.
Ligandrol has been making headlines in recent weeks for getting certain football players in trouble. Florida Gators quarterback Will Grier was recently suspended for PED usage. Grier was found to have Ligandrol in his system during a routine test.
Ligandrol is not officially classified as a steroid, but it is banned as a performance enhancing drug. As a result, Grier will serve a one year suspension. The quarterback is currently undergoing an appeals process and full details of the investigation have not been released. Most of the reports of the drug come from NFL insider-type sources – so we still have lots to learn.
One source published on TheBigLead.com claims that Grier took Ligandrol to gain 43 pounds. In his freshman year, Grier weighed 172 pounds. By his sophomore year, he had bulked up to 215 pounds.
Grier may be the most prominent Ligandrol user (that we know about). However, the drug is reportedly popular with a wide range of athletes and professionals, including:
— Athletes across all sports
How Does Ligandrol Work?
Ligandrol works as a selective androgen receptor modulator (SARM). That means it has a high affinity to bond with the androgen receptors. The “selective” part of the name comes from the fact that it only binds to androgen receptors in your muscles (not in your bones, or other areas of the body where androgen receptors are located).
The drug has legitimate medical uses in addition to being used as a performance enhancing drug. The LGD-4033 drug was originally developed to treat muscle wasting conditions (like muscular dystrophy). These conditions are linked with diseases like cancer, illness, and old age.
What to Expect When Taking Ligandrol
Gains of 1 to 1.5 pounds per week have been reported while taking LGD. These gains occur while eating slightly above maintenance calories on a high protein diet.
Many reviewers claim their gains are “steroid-like”.
There’s some controversy over Ligandrol because these weight gains could simply occur from glycogen supercondensation. In layman’s terms, that means the steroid-like properties of Ligandrol are telling your body to store more carbs and water than usual.
Once you’ve stopped taking Ligandrol and cycled off, you can expect to lose a bit of the weight you gained. These losses occur simply because your muscles are dropped glycogen.
How Much Ligandrol Should You Take?
Ligandrol is most commonly used at dosages of 5 to 10mg per day.
After 3 or 4 weeks, some users recommend increasing your dosage by 1 or 2mg. Cycle off Ligandrol every 6 to 12 weeks.
Any Side Effects of Ligandrol
Ligandrol has not been associated with any significant side effects thus far. However, that doesn’t mean that there aren’t any side effects.
Some studies, for example, have shown that Ligandrol can heavily suppress and lower free testosterone levels while also suppressing and lowering sex hormone binding globulin (SHBG) levels.
However, the good news is that after taking LGD-4033 it will only take a very short time (1 to 3 weeks) for your testosterone levels to get back to normal. Getting back to normal doesn’t take much time because Ligandrol does not affect LH or FSH.
There have also been no reported estrogenic system changes reported after taking LGD 4033. Nevertheless, some users will prefer to take an aromatase inhibitor regardless. A mini Post Cycle Therapy (PCT) treatment is recommended. However, it’s not necessarily required because Ligandrol does not affect you enough to influence libido problems or other unwanted side effects.
Finally, Ligandrol is not associated with liver toxicity: so you’re not doing long-term damage to your body’s organs.
Who Should Use Ligandrol?
Ultimately, Ligandrol is a legal steroid alternative that appears to work in a similar way to steroids – but without the dangerous side effects. As long as you’re not a Florida Gators quarterback (or playing sports that have banned PEDs), then Ligandrol could be an effective supplement to supercharge your bulking routine.